ITM and CNL Announce the Launch of Actineer

Using existing materials handling facilities and supporting infrastructure at the Chalk River Laboratories, CNL and ITM are also collaborating with other key strategic service providers to establish an interim supply of Ac-225. This project will deliver significant quantities of the high-demand radioisotope to healthcare professionals and patients before the APF is completed. 

Targeted alpha therapy is attracting growing interest from scientists and medical practitioners. Alpha-emitters, particularly Ac-225, are in high demand for their ability to cause damage to cancer cells. Notably, Ac-225 emits high-energy alpha particles with a short penetration range, which potentially enable precise treatment of tumor cells, including hard-to-target micro metastases, with minimal impact to surrounding healthy tissue. In preclinical studies, targeted alpha therapies have shown remarkable results, destroying cancer cells by effectively breaking the bonds in their DNA. Ac-225 can be labelled to a variety of peptide ligands or antibodies to specifically target cancer cells in a wide range of tumor indications.

About Targeted Alpha Therapy

Targeted Alpha Therapy is an emerging class of cancer therapeutics, which seeks to deliver alpha radiation directly to the tumor while minimizing radiation exposure to normal tissue. Targeted radiopharmaceuticals are created by linking a therapeutic radioisotope to a targeting molecule (e.g., peptide, antibody, small molecule) that can precisely recognize tumor cells and bind to tumor-specific characteristics, like receptors on the tumor cell surface. As a result, the radioisotope accumulates at the tumor site and decays, releasing a small amount of ionizing radiation, thereby destroying tumor tissue. The highly precise localization enables targeted treatment with minimal impact to healthy surrounding tissue.

About ITM Isotope Technologies Munich SE

ITM, a leading radiopharmaceutical biotech company, is dedicated to providing a new generation of radiomolecular precision therapeutics and diagnostics for hard-to-treat tumors. We aim to meet the needs of cancer patients, clinicians and our partners through excellence in development, production and global supply. With improved patient benefit as the driving principle for all we do, ITM advances a broad precision oncology pipeline, including two phase III studies, combining the company’s high-quality radioisotopes with a range of targeting molecules. By leveraging our nearly two decades of pioneering radiopharma expertise, central industry position and established global network, ITM strives to provide patients with more effective targeted treatment to improve clinical outcome and quality of life.

www.itm-radiopharma.com

About AECL

AECL drives nuclear innovation to deliver clean energy technologies and improve the quality of life of Canadians while caring for the land. As a federal Crown corporation, AECL’s mandate is to enable nuclear science and technology, derive optimal value for Canada from AECL’s CANDU intellectual property and to protect the environment by fulfilling the Government of Canada’s radioactive waste and decommissioning responsibilities.

AECL delivers its mandate through a Government-owned, Contractor-operated model, whereby a private-sector organization, Canadian Nuclear Laboratories, is responsible for managing and operating AECL’s sites. 
Under the Government-owned, Contractor-operated model, AECL owns the sites, facilities, assets, intellectual property and responsibility for nuclear science and technology, environmental remediation and radioactive waste management. Canadian Nuclear Laboratories is responsible for the day-to-day management and operations of the sites.

To learn more about AECL, please visit www.aecl.ca.

About CNL

As Canada’s premier nuclear science and technology laboratory, and working under the direction of Atomic Energy of Canada Limited (AECL), CNL is a world leader in the development of innovative nuclear science and technology products and services. Guided by an ambitious corporate strategy - Vision 2030, CNL fulfills three strategic priorities of national importance – restoring and protecting the environment, advancing clean energy technologies, and contributing to the health of Canadians.

By leveraging the assets owned by AECL, CNL also serves as the interface between government, the nuclear industry, the broader private sector and the academic community. CNL works in collaboration with all these sectors to advance innovative Canadian products and services for real-world use, including clean energy, cancer treatments and other therapies, non-proliferation technologies and waste management solutions.

To learn more about CNL, please visit www.cnl.ca.